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Applies only to oral form of both agents. This topic . informational and educational purposes only. Ferric gluconate: 12.5 mg/mL Schrier SL, Mentzer WC, Landaw SA. Below the form there are further instructions on how to use the calculator. Avoid or Use Alternate Drug. Dosage Calculator Oral and parenteral products - see background option for oral products. NOTES: Lab and/or medical tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be done while you are using this medication. Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). Talk to your pharmacist for more details.During pregnancy, this medication should be used only when clearly needed. Monofer 100mg/ml solution for injection/infusion - Summary of Product Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Avoid or Use Alternate Drug. Applies only to oral form of both agents. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. By using this form you agree with the storage and handling of your data by this website. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. and formulary information changes. iron sucrose decreases levels of ibandronate by inhibition of GI absorption. PDF Iron Sucrose: Guidelines for Administration Document Type: Guideline For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Applies only to oral form of both agents. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Administer Venofer early during the dialysis session (generally within the first hour). Monitor Closely (1)aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Administer Feraheme as an intravenous infusion in 50-200 mL 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP over at least 15 minutes. Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. Use Caution/Monitor. Hemodialysis-dependent: 0.5 mg/kg IV q2weeks for 12 weeks; not to exceed 100 mg/dose, Non-dialysis dependent or peritoneal-dependent (on erythropoietin): 0.5 mg/kg IV q4weeks for 12 weeks; not to exceed 100 mg/dose, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, Serious hypersensitivity reactions reported, including anaphylactic-type reactions, some of which have been life-threatening and fatal, Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse, If hypersensitivity reactions or signs of intolerance occur during administration, stop infusion immediately, Monitor patients for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes and until clinically stable following completion of the infusion, Animal reproduction studies of iron sucrose administered to rats and rabbits during period of organogenesis at elemental iron doses equivalent to maximum recommended human dose based on body surface area revealed no evidence of harm to the fetus; adverse outcomes in pregnancy occur regardless of health of mother or use of medications, Iron deficiency anemia during pregnancy should be treated; untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia; adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight, HD-dependent and non-dialysis-dependent CKD: Dilute with up to 100 mL of 0.9% NaCl, PD-dependent CKD: Dilute with up to 250 mL of 0.9% NaCl, Undiluted: Administer by slow IV injection over 2-5 min, Diluted solutions: Administer IV over 15 min, Undiluted: Administer by slow IV injection over 5 minutes, Diluted solutions: Administer IV over 5-60 minutes, Store in original carton at 20-25C (68-77 F); excursions permitted to 15- 30C (59-86F), Syringe: Store at room temperature (25C) or under refrigeration (4C) for up to 7 days, IV infusion: Store at room temperature (25C) for up to 7 days. Monitor Closely (1)iron sucrose decreases levels of deferiprone by enhancing GI absorption. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Comparable efficacy to that of IV iron sucrose. Use Caution/Monitor. Use Caution/Monitor. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Max Dose. Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Avoid or Use Alternate Drug. Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. Copyright 2021 GlobalRPH - Web Development by. Philadelphia, PA: Lippincott Williams & Wilkins;2013;303-307. Use Caution/Monitor. Schrier SL, Mentzer WC, Landaw SA. VENOFER (IRON SUCROSE INJECTION,USP) 100mg ELEMENTAL IRON - DailyMed Applies only to oral form of both agents. Minor/Significance Unknown. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Minor/Significance Unknown. LBW = Lean body weight in kg. Consult your pharmacist or local waste disposal company. All Rights Reserved. Before using, check this product visually for particles or discoloration. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. Applies only to oral form of both agents. Use Caution/Monitor. Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)- . . Serious - Use Alternative (1)iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. PDF Venofer Guidelines for Use 2011 - University Health System Avoid or Use Alternate Drug. Individual plans may vary Administer a test INFeD dose prior to the first therapeutic dose. Use Caution/Monitor. Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. 2. Evaluate the hematologic response (hemoglobin, ferritin, iron and transferrin saturation) at least one month following the second Feraheme infusion. Calculosaurus | Ferinject dose calculator Deferasirox chelates iron. Venofer must only be administered intravenously either by slow injection or by infusion. FERAHEME Dosing & Administration - Feraheme The dosage of Venofer is expressed in mg of elemental iron. Applies only to oral form of both agents. Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).] Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products (such as Venofer) which may cause fetal bradycardia, especially during the second and third trimester. Anaphylaxis may occur with IV iron and resuscitation facilities should be available.11 It would appear that iron polymaltose may have a higher incidence of severe systemic reactions than iron sucrose and ferric carboxymaltose. Where C is the concentration of the iron product: Please note that the calculations above are for information purposes only and the individual dose needs to be established by taking into account the current package insert for the elemental iron product used. Available for Android and iOS devices. . Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. Applies only to oral form of both agents. Administer on 5 different occasions over a 14 day period. Venofer treatment may be repeated if necessary. Parenteral iron dextran therapy: a review. Monitor for signs and symptoms of hypotension following each administration of Venofer. Deferoxamine chelates iron. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Calculation of Dosage of Nefrofer Total Iron Deficit (mg) Nefrofer (ml) = 20mg/ml Total Iron Deficit (mg) = Body weight (kg) x (Target Hb - Actual Hb) [g/l] x 0.24* + Depot Iron . Applies only to oral form of both agents. iron sucrose increases levels of calcium gluconate by enhancing GI absorption. Allow at least 30 minutes between administration of Feraheme and administration of other medications that could potentially cause serious hypersensitivity reactions and/or hypotension, such as chemotherapeutic agents or monoclonal antibodies. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Anemia; 2015: 763576. UpToDate. You can further save the PDF or print it. Drug class: Iron products. The recommended dosage of iron sucrose for repletion of iron deficiency in patients undergoing hemodialysis is 5ml of iron sucrose (100mg of elemental iron) delivered intravenously during the dialysis session. Minor/Significance Unknown. The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran. Recommended Treatment Regimen Using IV Iron Sucrose for Initial Repletion in Children With Iron Deficiency Anemia. iron sucrose decreases levels of liothyronine by inhibition of GI absorption. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14. Venofer treatment may be repeated if necessary. May increase risk of hypotension. iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Each mL contains 20 mg of elemental iron. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Modify Therapy/Monitor Closely. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. Contraindicated. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. ADMINISTER THE TEST DOSE AT A GRADUAL RATE OVER AT LEAST 30 SECONDS. VenAccess is a trademark of Vifor (International) Inc. Switzerland. Venofer (iron sucrose) dose calculator | Calculosaurus.com commonly, these are "non-preferred" brand drugs. Intravenous (IV) iron products (use in adults) Dosing information in this table is for adults and includes some dosing recommendations not listed in the approved product information. Each costs about $0.46 to $0.55 per mg of iron. The dosing for iron replacement treatment in pediatric patients with Peritoneal or Hemodialysis-Dependent - CKD or Non-Dialysis Dependent CKD have not been established. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Medscape Education, Improving Quality of Care in Patients With Iron Deficiency Anemia and Inflammatory Bowel Disease, 2010feosol-carbonyl-fe-icar-c-carbonyl-iron-342171Drugs, encoded search term (iron sucrose (Venofer)) and iron sucrose (Venofer), Use of High-Dose Iron in Dialysis in US Tracks PIVOTAL Trial, FDA Watch List Adds Drugs With Anaphylaxis, Herpes, Fetal Death Risk, Dialysis Industry Mergers: Profits Rise as Patient Outcomes Worsen, Hematology-Oncology Guidelines: 2017 Midyear Review. 2015: 763576. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. Med J Aust; 193(9):525-32. SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. Alldredge BK, Corelli RL, Ernst ME, Guglielmo BJ, eds. Fatal reactions have followed the test dose of iron dextran injection. sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Maximum infusion rate: 100 mg / hour (Slow infusion rate of iron sucrose is recommended to minimize adverse reactions, especially hypotension) Frequency of infusion: Dose may be repeated up to 3 times weekly to provide total iron dose. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) Most adults require a cumulative dose of elemental iron of at least 1 g. Iron replenishment is usually doneintravenously, via iron-dextran, iron sucrose or iron carboxymaltose. Use Caution/Monitor. Am J Kid Dis 2001; 38 988991. Minor/Significance Unknown. Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Adults and Children over 15 kg (33 lbs): Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW), Desired Hb = the target Hb in g/dl. IV iron products (adults) - UpToDate Dosing: (a) Divide calculated total cumulate dose . All adult and pediatric patients receiving Venofer require periodic monitoring of hematologic and iron parameters (hemoglobin, hematocrit, serum ferritin and transferrin saturation). PDF Venofer - Food and Drug Administration Venofer Dosing and Administration Avoid or Use Alternate Drug. US residents can call their local poison control center at 1-800-222-1222. Intravenous iron sucrose: establishing a safe dose - PubMed 3. 1970; 100(7):301-3. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Deferoxamine chelates iron. Canada residents can call a provincial poison control center. Always ask your health care professional for complete information about this product and your specific health needs. Formula for calculating the required dose of iron sucrose 2.1 Dosage - Total dose infusion The dose calculation for CosmoFer is based on patients body weight according to the table below and is diluted in 500mLs of normal saline. Use Caution/Monitor. iron sucrose decreases levels of manganese by inhibition of GI absorption. Test Dose: Not required. We'll do this entirely for free, as long as the calculator has applications for women's health. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time.Your dosage and length of treatment are based on your medical condition, age, and response to treatment. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. On the other hand, slow decreases, such as that in chronic occult gastrointestinal bleeding are often difficult to diagnose. Applies only to oral form of both agents. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . This website also contains material copyrighted by 3rd parties. Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in Hemoglobin there are two fields for hemoglobin input, one for the target and another for actual value. Calculation of total iron deficit for initial repletion: [29] Total cumulative dose (mg) = [Target Hb Actual Hb] weight (kg) 2.4 + [15 weight (kg)] *Hb in g/dl: 2. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Use Caution/Monitor. Consult your doctor before breast-feeding. Use Caution/Monitor. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. The dosing of Monofer was performed according to the Simplified Table as described in section 4.2 above and dosing of iron sucrose was calculated according to Ganzoni and administered as 200 mg infusions. Either decreases levels of the other by inhibition of GI absorption. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Calculation of Iron Deficit - Perinatology.com 0.5 mg/kg (not to exceed 100 mg/dose) diluted to a concentration of 1 to 2 mg/mL in 0.9% sodium chloride IV over 5 to 60 minutes Administer every 4 weeks for 12 weeks Do not dilute to concentrations below 1 mg/mL Comments: Treatment may be repeated if necessary. Ferritin and transferrin are also recommended monitoring . Manufacturer advises for slow intravenous injection ( Venofer ), give undiluted at a rate of 1 mL/minute; do not exceed 10 mL (200 mg iron) per injection. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Iron Sucrose Dosage Guide + Max Dose, Adjustments - Drugs.com Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. This website is intended for use by US healthcare professionals only. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Human studies not conducted. Applies only to oral form of both agents. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Results: Twelve children (6 females) aged 1.2-14 years (median age 8.9 years) received at least one dose of . Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. Serious hypersensitivity reactions, including anaphylactic-type reactions, some of which have been life-threatening and fatal, have been reported in patients receiving Venofer. [. Either decreases levels of the other by inhibition of GI absorption. 2.1 . Our dosage calculator can help you with this as well. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia Equations used: 1] Calculation of the Total Iron Deficit: Total iron deficit [mg] = body weight [kg] x (target Hb-actual Hb) [g/dl] x 2.4 + depot iron [mg]. Iron sucrose: 20 mg/mL. Use alternatives if available. Clinical calculators for obstetrics and gynaecology - calculosaurus Do Not Copy, Distribute or otherwise Disseminate without express permission. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. There are four fields that need to be completed: Weight body weight is used to establish iron deficit and is also taken into account when estimating the iron stores. Minor/Significance Unknown. Applies only to oral form of both agents. Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Monitor for signs and symptoms of hypotension following each Feraheme infusion. Generic name: IRON SUCROSE 20mg in 1mL iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients. nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Most Calculation of the Total Iron Deficit - Alternative equation Applies only to oral form of both agents. . Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Many patients with kidney disease cannot get enough iron from food and require injections. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. official version of the modified score here. Avoid or Use Alternate Drug. Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Minor (2)calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. Monitor Closely (1)famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. 4)Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Pain, swelling, or redness at the injection site may occur. iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Treatment of iron deficiency anemia in adults - UpToDate This medicine is sometimes given slowly, and the infusion can take up to 2.5 hours to complete. Separate dosing of tetracyclines from these products. Dilute Venofer in a maximum of 250 mL of 0.9% NaCl [see How Supplied/Storage and Handling (16.2).] The weight of the patient is taken into account in order to estimate iron stores, while haemoglobin is required as both current measured and target. Interaction only with oral iron administration. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. No additional iron to replenish stores. Human studies not conducted. The recommended Feraheme dose may be readministered to patients with persistent or recurrent iron deficiency anemia. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. Applies only to oral form of both agents. Safety of highdose iron sucrose infusion in hospitalized patients with chronic kidney disease. This site complies with the HONcode standard for trust- worthy health information: verify here. Most These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Fulminant symptoms may include general paleness, confusion or episodes of passing out. Suggested regime: Prescribing instructions Prescribing a single/first dose: In a randomized, open-label, dose-ranging trial for iron maintenance treatment with Venofer in pediatric patients with CKD on stable erythropoietin therapy [see Clinical Studies ( 14.7)], at least one adverse reaction was experienced by 57% (27/47) of the patients receiving Venofer 0.5 mg/kg, 53% (25/47) of the patients receiving Venofer 1 mg .